Thread Biosecurity and Viral Research / Original thread
CRISPR and Hantavirus Research Literature Review
Original posts. Original order. Sources and media stay with them.
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May 7, 20268posts9source URLs15archived media items
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1/ Let's turn this into another specifically targeted thread underneath your tags!
We conducted an exhaustive search of peer-reviewed literature for collaborative CRISPR or genomic editing research on hantavirus involving both Chinese and American scientists/researchers—covering any work since 1980 on both host-side and pathogen-side genomic interventions.
The search spanned:
PubMed, Web of Science, bioRxiv
International databases
Institutional repositories
50 specific search queries combining: hantavirus, CRISPR, genomic editing, China, USA, collaboration
🔍 Here's what we found:
We conducted an exhaustive search of peer-reviewed literature for collaborative CRISPR or genomic editing research on hantavirus involving both Chinese and American scientists/researchers—covering any work since 1980 on both host-side and pathogen-side genomic interventions.
The search spanned:
PubMed, Web of Science, bioRxiv
International databases
Institutional repositories
50 specific search queries combining: hantavirus, CRISPR, genomic editing, China, USA, collaboration
🔍 Here's what we found:
2/ WHAT WE DID FIND: Standalone CRISPR Hantavirus Work
China-Only CRISPR Research:🧪 "Sensitive & Visualized Detection of Hantavirus Using CRISPR/Cas12a" (2025, J Med Virol)
Wuhan University, Southern Medical University, CAMS, South China University of Technology
AutoCORDSv2-designed CRISPR detection system
42 copies/reaction sensitivity
All Chinese authors & institutions (1)
China-Only CRISPR Research:🧪 "Sensitive & Visualized Detection of Hantavirus Using CRISPR/Cas12a" (2025, J Med Virol)
Wuhan University, Southern Medical University, CAMS, South China University of Technology
AutoCORDSv2-designed CRISPR detection system
42 copies/reaction sensitivity
All Chinese authors & institutions (1)
3/ WHAT WE DID FIND: USA/International CRISPR Research
American-Led Work (No Chinese Collaborators):
🧪 "Genetic Depletion Studies Inform Receptor Usage"
Albert Einstein College of Medicine, University of New Mexico, University of Colorado
CRISPR/Cas9 knockout of hantavirus entry receptors (PCDH1, DAF, ITGB3, ITGB1)
New-World vs Old-World receptor differences (2)
Swedish collaborator (Jonas Klingström, Karolinska)
🧪 "Amplification-Free Detection Using Cas13" (2025, J Gen Virol)
Princeton University lead; German & Swedish collaborators
No Chinese authors (3)
American-Led Work (No Chinese Collaborators):
🧪 "Genetic Depletion Studies Inform Receptor Usage"
Albert Einstein College of Medicine, University of New Mexico, University of Colorado
CRISPR/Cas9 knockout of hantavirus entry receptors (PCDH1, DAF, ITGB3, ITGB1)
New-World vs Old-World receptor differences (2)
Swedish collaborator (Jonas Klingström, Karolinska)
🧪 "Amplification-Free Detection Using Cas13" (2025, J Gen Virol)
Princeton University lead; German & Swedish collaborators
No Chinese authors (3)
4/ WHAT WE DID FIND: Chinese-American Hantavirus Collaboration (But NOT CRISPR)
The ONLY China-USA hantavirus co-authored papers involved virus discovery or epidemiology, NOT genomic editing:
☑️ "Fugong Virus: Novel Hantavirus in Chinese Mole Shrew" - Wuhan Institute of Virology (China), EcoHealth Alliance, New York (USA)
Virus characterization, NOT gene editing (4)
☑️ "Cao Bang Hantavirus in Mole Shrews" - University of Hawaii, Chinese institutions
Genetic diversity mapping, NOT CRISPR (5)
☑️ "Reservoir Host Expansion" - Shandong University (China) + UT Medical Branch (USA)
Epidemiology, NOT genomic editing (6)
The ONLY China-USA hantavirus co-authored papers involved virus discovery or epidemiology, NOT genomic editing:
☑️ "Fugong Virus: Novel Hantavirus in Chinese Mole Shrew" - Wuhan Institute of Virology (China), EcoHealth Alliance, New York (USA)
Virus characterization, NOT gene editing (4)
☑️ "Cao Bang Hantavirus in Mole Shrews" - University of Hawaii, Chinese institutions
Genetic diversity mapping, NOT CRISPR (5)
☑️ "Reservoir Host Expansion" - Shandong University (China) + UT Medical Branch (USA)
Epidemiology, NOT genomic editing (6)
5/ THE RESEARCH LANDSCAPE: Why This Matters
Despite substantial bilateral collaboration in virology, the absence of Chinese-American CRISPR/hantavirus research is notable because:
📊 CRISPR Innovation Leaders:
China: First CRISPR embryo editing (2015), embryo immunity trials (2018)
USA: Princeton, MIT, UC Berkeley CRISPR pioneers
Both nations have top-tier BSL-4 facilities
🤝 Existing Collaborations:
🚨Wuhan Institute ↔ University of Texas (coronavirus work)
🚨EcoHealth Alliance ↔ Chinese institutions (viral discovery)
🚨Baric (UNC) ↔ Shi Zhengli (WIV) partnerships
Despite substantial bilateral collaboration in virology, the absence of Chinese-American CRISPR/hantavirus research is notable because:
📊 CRISPR Innovation Leaders:
China: First CRISPR embryo editing (2015), embryo immunity trials (2018)
USA: Princeton, MIT, UC Berkeley CRISPR pioneers
Both nations have top-tier BSL-4 facilities
🤝 Existing Collaborations:
🚨Wuhan Institute ↔ University of Texas (coronavirus work)
🚨EcoHealth Alliance ↔ Chinese institutions (viral discovery)
🚨Baric (UNC) ↔ Shi Zhengli (WIV) partnerships
6/ Citations:
#1 CRISPR/Cas12a Hantavirus Detection https://t.co/QuQJi7mNXw
#2 Genetic Depletion Studies - eLife https://t.co/tZ8qf6FWr9 https://t.co/ciWCIS7S7D
#3 Cas13 Detection - Journal of General Virology https://t.co/mKfpnraMJa
#4 Fugong Virus Paper https://t.co/1UVbuUNQgv
#5 Cao Bang Hantavirus - Mole Shrews https://t.co/4tVOt9f0lQ
#6 Reservoir Host Expansion - China https://t.co/SyZAaNrJZI
#7 Hantavirus Entry Review https://t.co/TgGjDueJvT
#8 Bibliometric Analysis (1980-2020) https://t.co/iqp6VhFFGr
#1 CRISPR/Cas12a Hantavirus Detection https://t.co/QuQJi7mNXw
#2 Genetic Depletion Studies - eLife https://t.co/tZ8qf6FWr9 https://t.co/ciWCIS7S7D
#3 Cas13 Detection - Journal of General Virology https://t.co/mKfpnraMJa
#4 Fugong Virus Paper https://t.co/1UVbuUNQgv
#5 Cao Bang Hantavirus - Mole Shrews https://t.co/4tVOt9f0lQ
#6 Reservoir Host Expansion - China https://t.co/SyZAaNrJZI
#7 Hantavirus Entry Review https://t.co/TgGjDueJvT
#8 Bibliometric Analysis (1980-2020) https://t.co/iqp6VhFFGr
9source links
- https://onlinelibrary.wiley.com/doi/10.1002/jmv.70460
- https://elifesciences.org/articles/69708
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8263056/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12582395/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754816/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4844841/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4285249/
- https://ncbi.nlm.nih.gov/pmc/articles/PMC6881143
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526533/
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